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KMID : 1101820210090010010
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Journal of Breast Disease
2021 Volume.9 No. 1 p.10 ~ p.15
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Clinicopathological Features and Prognosis of Lobular Carcinoma In Situ
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Lee Jee-A
Ku Ga-Yoon
Park Hyung-Seok
Lee Hae-Min
Ku Ja-Seung
Kim Jee-Ye
Park Se-Ho
Kim Seung-Il
Park Byeong-Woo
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Abstract
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Purpose: According to the American Joint Committee on Cancer’s 8th Edition Manual, lobular carcinoma in situ (LCIS) is no longer considered a malignant disease, although it may be a precursor to the development of breast cancer. The present study aimed to evaluate the clinicopathological features and prognosis of LCIS.
Methods: This study retrospectively analyzed clinicopathological features and prognosis data of LCIS among patients who underwent breast surgery at Severance Hospital, Seoul, South Korea from 1991 to 2016.
Results: Of the 47 patients, 49 cases of LCIS were confirmed by postoperative pathology. The mean patient age was 48.15±8.34 years. Most patients (81.6%) did not have palpable tumors at diagnosis, and 51.0% showed no microcalcification on mammography. Breast-conserving surgery was performed more frequently than total mastectomy (77.6% vs. 22.4%). The mean tumor size was 1.63±2.11 cm. There were only 3 cases of pleomorphic LCIS. Hormone receptor-positive tumors were noted in 47 cases, however, the hormone receptor status was unknown in the other 2 cases. There were no LCIS recurrences or deaths during the follow-up period (mean 56 months).
Conclusions: LCIS is often incidentally diagnosed without clinical symptoms, especially in women aged <50 years. The prognosis of LCIS is excellent in cases that are surgically treated.
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KEYWORD
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Core needle biopsy, Lobular carcinoma in situ, Prognosis
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